KPV (Lysine-Proline-Valine)

KPV is a naturally occurring tripeptide that represents the C-terminal fragment of Alpha-Melanocyte Stimulating Hormone (α-MSH). Despite its relation to α-MSH, KPV does not trigger pigmentation; instead, it is a fierce anti-inflammatory agent. It operates by entering inside cells and interacting directly with inflammatory pathways, blocking the nuclear translocation of NF-κB (the master switch for systemic inflammation). This significantly diminishes the production of inflammatory molecules. It is heavily researched for auto-immune conditions, inflammatory bowel disease (IDB/Colitis), severe eczema, and mast cell activation syndrome (MCAS).